Granulomatous slack skin: a distinct disorder or a variant of mycosis fungoides?
نویسندگان
چکیده
About 75% of cutaneous lymphomas belong to the group of T-cell lymphomas. Mycosis fungoides is the most common entity in this group. Granulomatous slack skin is a rare form of cutaneous T-cell lymphoma closely related to mycosis fungoides. We present here a patient with areas of lax skin for several years who developed a generalized erythroderma with associated immunoactivation and a deterioration in his general condition. This report discusses clinically and histologically the differential diagnoses, namely granulomatous slack skin and granulomatous mycosis fungoides, and suggests that these 2 disorders are only variants in the broad spectrum of a single disease.
منابع مشابه
Slack Skin Syndrome with Granulomatous Involvement of the Lungs: A Case Report and Literature Review
Granulomatous slack skin syndrome is a rare variant of mycosis fugoides characterized by the development of pendulous skin folds in the intertriginous regions. It has an indolent but progressive course and is usually refractory to treatment. Extra-cutaneous involvement is rare. We report a unique case of slack skin syndrome coexisting with a progressive granulomatous lung disease.
متن کاملEvaluation of Variant Lymphocyte Count in Peripheral Blood Smear of Patients with Mycosis Fungoides and Its Comparison with the Normal Population
Background and Objective: Mycosis fungoides is a neoplastic skin disorder whose underlying cause is not yet fully understood. There are hypotheses about the possible effect of viral agents on the development of mycosis fungoids that have not yet been proven. The present study aimed to evaluate the lymphocyte variant in peripheral blood smear of patients with mycosis fungoides fungoids to determ...
متن کاملGranulomatous slack skin: a rare subtype of mycosis fungoides*
We report a case of granulomatous slack skin, a rare and indolent subtype of mycosis fungoides. It affects mainly men between the third and fourth decades. It is characterized by hardened and erithematous plaques that mainly affect flexural areas and become pedunculated after some years. Histological examination shows a dense infiltrate of small atypical lymphocytes involving the dermis (and so...
متن کاملMycosis fungoides: a dermatological masquerader.
Mycosis fungoides (MF), a low-grade lymphoproliferative disorder, is the most common type of cutaneous T-cell lymphoma. Typically, neoplastic T cells localize to the skin and produce patches, plaques, tumours or erythroderma. Diagnosis of MF can be difficult due to highly variable presentations and the sometimes nonspecific nature of histological findings. Molecular biology has improved the dia...
متن کاملGranulomatous slack skin presenting as diffuse poikiloderma and necrotic ulcers, with features of granulomatous vasculitis and response to oral prednisone, acitretin, and oral psoralen plus ultraviolet light therapy—A case report
GSS: granulomatous slack skin PUVA: psoralen plus ultraviolet A therapy INTRODUCTION Granulomatous slack skin (GSS), a rare variant of mycosis fungoides, is characterized clinically by bulky, pendulous skin folds on flexural areas and histologically by elastolytic granulomatous infiltrates of clonal T cells. The monoclonal rearrangement of the T-cell receptor b and g genes can be demonstrated b...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Acta dermato-venereologica
دوره 81 1 شماره
صفحات -
تاریخ انتشار 2001